The Curbsiders Internal Medicine Podcast

#496 Hotcakes: Cannabidiol (CBD)-induced liver injury, IV iron for HFrEF, bedtime BP meds, Carpal Tunnel Syndrome & RA, & Finerenone for HFpEF

Mon, 25 Aug 2025

Join us as we review recent practice-changing articles on cannabidiol (CBD)-induced liver injury, IV iron for HFrEF, bedtime administration of blood pressure meds, carpal tunnel syndrome & rheumatoid arthritis , & FDA approval of finerenone for HFpEF. Fill your brain hole with a delicious stack of hotcakes! Featuring Paul Williams (@PaulNWilliamz), Rahul Ganatra (@rbganatra), Nora Taranto (@norataranto) and Matt Watto (@doctorwatto).

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Credits

Written and Hosted by: Rahul Ganatra MD, MPH; Nora Taranto MD, Paul Williams, MD, FACP, Matthew Watto MD, FACP

Cover Art: Rahul Ganatra MD, MPH

Reviewer: Emi Okamoto, MD

Technical Production: Pod Paste

Showrunners: Matthew Watto MD, FACP; Paul Williams MD, FACP

Show Segments

Intro, disclaimer

CBD-induced liver injury

IV Iron in HFrEF

Bedtime administration of BP medications

Carpal tunnel syndrome and RA

FDA approves Finerenone for HFpEF

Outro

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#495 Fungal Infections -Histo/Blasto/Cocci with Dr. Andrej Spec

Mon, 18 Aug 2025

Why we need to stop calling them “endemic” mycoses & more fungi fun!

Feeling muddled about endemic mycoses? We tackle the clinical presentation of diseases like histoplasmosis, blastomycosis, and coccidioidomycosis, the importance of testing, and how to diagnose fungal infections with our esteemed guest Dr. Andrej Spec, MD!

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Show Segments

Introduction and icebreaker, Fish Club?! 00:00

Case 1 from Kashlak 07:27

Diagnostic framework for dimorphic fungi 11:58

Imaging presentations for fungal pneumonia, diagnostic schemas 18:23

Testing options 27:48

Treatment options 35:44

Dimorphic Fungi Mnemonics 45:50

Retail testing for mold 48:47

Case 2 from Kashlak 56: 42

Takeaways and Conclusions 1:05:19

Credits

Producer, Writer, Show Notes: Beth “Garbs” Gasperlin MD

Infographic and Cover Art: Zoya Surani

Hosts: Matthew Watto MD, FACP; Paul Williams MD, FACP, Beth Gasperlin MD

Reviewer: Leah Witt Gaspard MD

Showrunners: Matthew Watto MD, FACP; Paul Williams MD, FACP

Technical Production: PodPaste

Guest: Andrej Spec MD

Disclosures

Dr. Spec reports no relevant financial disclosures. The Curbsiders report no relevant financial disclosures.

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#494 C. diff, Diarrhea, the Microbiome, and New Therapies with Dr. Cynthia Sears. Live from Johns Hopkins Grand Rounds

Mon, 11 Aug 2025

Dominate C. diff! Learn to distinguish colonization from infection, select first-line therapies, and counsel patients on recurrence prevention and microbiome recovery. We’re joined by IDSA past president and expert on foodborne and intestinal infections, Dr. Cindy Sears (Johns Hopkins University) for a comprehensive update on Clostridioides difficile (C. diff, Cdiff, CDAD, CDI).

Claim CME for this episode at curbsiders.vcuhealth.org!

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Show Segments

00:00 Intro

03:00 Guest bio and hobby

04:25 Case of Charles Fleur Fontaine

06:00 Risk factors and epidemiology

08:00 Antibiotic hierarchy of risk

10:00 Diagnosis, testing strategies

14:00 Defining severity

17:30 Treatment options

20:00 Microbiome recovery strategies

24:00 Probiotics and postbiotics

27:00 Infection control counseling

30:00 C. diff and colon cancer

32:00 Recurrent C. diff strategies

35:00 Why some FMT and bezlotoxumab were discontinued

38:00 Microbiota replacement therapies

43:00 Prophylaxis strategies

45:00 Future therapies and ongoing research

47:00 Audience Q&A

52:00 Outro

Credits

Written and Produced by: Matthew Watto, MD, FACP

Cover Art and Infographic by:

Hosts: Matthew Watto MD, FACP; Paul Williams MD, FACP

Reviewer: Sai S Achi MD,MBA,FACP

Showrunners: Matthew Watto MD, FACP; Paul Williams MD, FACP

Technical Production: PodPaste

Guest: Cynthia Sears MD

Disclosures

Dr. Sears reports no relevant financial disclosures. Dr. Williams financial relationships disclosed include a Merck grant or research support. This relationship has not ended.

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Bonus: Hypermobility Q&A with Bendy Bodies Dr. Linda Bluestein

Thu, 07 Aug 2025

In this special bonus episode, Dr. Linda Blustein (Bendy Bodies https://bit.ly/m/BendyBodies) addresses listener questions about Ehlers-Danlos syndrome (EDS) and hypermobility spectrum disorders.

00:00 – Introduction

00:59 – Can PCPs diagnose hEDS without a geneticist?

03:19 – Limitations of the Beighton Score

05:40 – 2017 hEDS criteria & upcoming revisions

10:29 – How to find a knowledgeable provider

12:52 – SVT vs POTS in a patient with EDS family history

19:53 – How to ask your provider if they’re comfortable treating dysautonomia

22:17 – MTHFR variants and hEDS

29:23 – Celiac, gluten sensitivity & EDS

31:48 – Food allergy vs sensitivity testing

34:11 – Lipoedema and hypermobility

39:00 – LDN, Ketotifen, and Cromolyn

43:41 – Medication sensitivity in EDS/POTS/MCAS patients

45:47 – Wrap up and resources

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REBOOT: #452 NAFLD/MASLD with Dr. Elliot Tapper

Mon, 04 Aug 2025

We have a classic Curbsiders episode for you. Expert guest Dr. Elliot Tapper (@ebtapper) shares his framework for approaching NAFLD/MASLD and the treatment tools he recommends including lifestyle modifications and medications.